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\u5b9f\u969b\u98f2\u3093\u3060\u4eba\u306e\u58f0\u306f\uff1f<\/h2>\n
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\n\uff21\u3055\u307e\u306f2021\u5e749\u6708\u304b\u3089\u30d5\u30a9\u30b7\u30fc\u30ac\u3092\u98f2\u307f\u59cb\u3081\u305f\u3068\u3053\u308d\u30011\u304b\u6708\u5f8c\u306e\u691c\u67fb\u3067\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u304c\u4e0a\u6607\u3057\u3001eGFR\u3082\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002
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A\u3055\u307e\u306f\u3001\u300c\u307e\u3060\u307e\u3060\u3001\u4e0d\u900f\u660e\u611f\u304c\u3042\u308a\u4e00\u559c\u4e00\u6182\u3059\u308b\u3068\u3053\u308d\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u85ac\u52b9\u3092\u4fe1\u3058\u3066\u7d4c\u904e\u3092\u307f\u305f\u3044\u300d\u3068\u8a9e\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n
A\u69d8\u306e\u7d20\u6674\u3089\u3057\u3044\u3068\u3053\u308d\u306f\u3001\u7591\u554f\u70b9\u3092\u533b\u5e2b\u3084\u85ac\u5264\u307e\u304b\u306b\u305b\u305a\u3001\u3054\u81ea\u5206\u3067\u88fd\u85ac\u4f1a\u793e\u306b\u554f\u5408\u305b\u3066\u3044\u308b\u3068\u3053\u308d\u3060\u3068\u601d\u3044\u307e\u3059\u3002 B\u3055\u307e\u306e\u304a\u8a71\u3092\u805e\u3044\u3066\u7d14\u70ad\u793e\u9577\u304c\u771f\u3063\u5148\u306b\u601d\u3044\u51fa\u3057\u305f\u306e\u306f\u3001\u6700\u8fd1\u8cfc\u5165\u3057\u305f\u30ec\u30b8\u30c7\u30f3\u30b9\u30ce\u30fc\u30c8\u5897\u520a\u300c\u814e\u75be\u60a3\u306e\u8a3a\u5bdf\u30fb\u691c\u67fb\u3067\u304d\u3066\u307e\u3059\u304b\uff1f\u300d\uff08\u7f8a\u571f\u793e\uff09206\u9801\u306b\u66f8\u304b\u308c\u3066\u3044\u305f\u4ee5\u4e0b\u306e\u6587\u7ae0\u3067\u3059\u3002 \u30d5\u30a9\u30b7\u30fc\u30ac\u306e\u526f\u4f5c\u7528\u3068\u3057\u3066\u5c3f\u91cf\u5897\u52a0\u306b\u3088\u308b\u8131\u6c34\u304c\u3042\u308a\u307e\u3059\u3002 B\u3055\u307e\u306e\u5834\u5408\u306f\u3001\u3054\u81ea\u8eab\u306e\u898b\u8b58\u3084\u4e3b\u6cbb\u533b\u306e\u5224\u65ad\u3067\u900f\u6790\u306b\u306f\u81f3\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u6ce8\u610f\u3059\u3079\u304d\u306f\u3001\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u3084eGFR\u304c\u900f\u6790\u5c0e\u5165\u57fa\u6e96\u306b\u6e80\u305f\u306a\u3044\u5834\u5408\u3067\u3082BUN\u304c\u8df3\u306d\u4e0a\u304c\u308a\u98df\u6b32\u4e0d\u632f\u3084\u5026\u6020\u611f\u3092\u611f\u3058\u3066\u3044\u308b\u3068\uff08\u672c\u5f53\u306f\u5fc5\u8981\u306a\u3044\u306e\u306b\uff09\u900f\u6790\u5c0e\u5165\u3055\u308c\u3066\u3057\u307e\u3046\u5834\u5408\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n \u304a\u533b\u8005\u69d8\u306b\u3057\u3066\u307f\u308c\u3070\u3001\u76ee\u306e\u524d\u306b\u98df\u6b32\u4e0d\u632f\u3084\u5026\u6020\u611f\u3092\u8a34\u3048\u308b\u6162\u6027\u814e\u4e0d\u5168\u60a3\u8005\u304c\u73fe\u308c\u308c\u305f\u3089\u3001\uff08\u900f\u6790\u5c0e\u5165\u3057\u305f\u3068\u3057\u3066\u3082\uff09\u7f8e\u5473\u3057\u304f\u98df\u3079\u3089\u308c\u3001\u8eab\u4f53\u3082\u8efd\u304f\u3001\u697d\u306b\u306a\u3063\u3066\u6b32\u3057\u3044\u3068\u9858\u3046\u306e\u304c\u5f53\u7136\uff08\u533b\u5e2b\u306e\u4f7f\u547d\uff09\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u3067\u3059\u304b\u3089\u3001\u8aa4\u3063\u3066\u900f\u6790\u306b\u5165\u3063\u3066\u3057\u307e\u3046\u3088\u3046\u306a\u3053\u3068\u304c\u7121\u3044\u3088\u3046\u306b\u3001\u30bb\u30ab\u30f3\u30c9\u30aa\u30d4\u30cb\u30aa\u30f3\u3092\u898b\u3064\u3051\u305f\u308a\u3001\u81ea\u5206\u81ea\u8eab\u306e\u75c5\u6c17\u306b\u95a2\u3059\u308b\u898b\u8b58\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5927\u5207\u3060\u3068\u601d\u3046\u306e\u3067\u3059\u3002<\/p>\n \u3010\u53c2\u8003\u3011 \u6ce8\uff1a\u7cd6\u5c3f\u75c5\u306b\u306f1\u578b\u30682\u578b\u306e\u4e8c\u3064\u306e\u30bf\u30a4\u30d7\u304c\u3042\u308a\u307e\u3059\u30021\u578b\u7cd6\u5c3f\u75c5\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306a\u3069\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u304c\u7834\u58ca\u3055\u308c\u3066\u3057\u307e\u3046\u30bf\u30a4\u30d7\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u304c\u5fc5\u8981\u3067\u3059\uff09\u30022\u578b\u7cd6\u5c3f\u75c5\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u5206\u6ccc\u3055\u308c\u308b\u3082\u306e\u306e\u3001\u5206\u6ccc\u91cf\u304c\u6e1b\u3063\u3066\u3057\u307e\u3063\u305f\u308a\u611f\u53d7\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3044\u3001\u8840\u7cd6\u5024\u304c\u9ad8\u3044\u307e\u307e\u306b\u306a\u308b\u30bf\u30a4\u30d7\u3067\u3059\u30022\u578b\u7cd6\u5c3f\u75c5\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3084\u904e\u98df\u30fb\u904b\u52d5\u4e0d\u8db3\u306a\u3069\u304c\u539f\u56e0\u3067\u767a\u75c7\u3057\u307e\u3059\uff08e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\u3088\u308a\u629c\u7c8b<\/a><\/span>\uff09<\/p>\n \u3010\u95a2\u9023\u8a18\u4e8b\u3011 \u660e\u3051\u307e\u3057\u3066\u304a\u3081\u3067\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3001\u7d14\u70ad\u793e\u9577\u306e\u6a0b\u53e3\u3067\u3059\u3002 2022\u5e74\u5bc5\u5e74\u3082\u7d14\u70ad\u7c89\u672b\u516c\u5f0f\u5c02\u9580\u5e97\u3092\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002 \u814e\u81d3\u75c5\u306e\u65b0\u85ac\u627f\u8a8d\u306e\u30cb\u30e5\u30fc\u30b9 \u3055\u3066\u30012021\u5e74\u306e\u30c8\u30d4\u30c3\u30af\u30b9\u306f\u4f55\u3068\u3044\u3063\u3066\u3082\u30d5\u30a9\u30b7\u30fc\u30ac\u304c\u6162\u6027\u814e\u81d3\u75c5\u6cbb\u7642\u85ac\u3068\u3057 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\n\u81ea\u5206\u304c\u98f2\u3093\u3067\u3044\u308b\u85ac\u306b\u3064\u3044\u3066\u77e5\u308a\u305f\u3044\u5834\u5408\u306f\u3001\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u3000\u533b\u85ac\u54c1\u533b\u7642\u6a5f\u5668\u7dcf\u5408\u6a5f\u69cb\u306e\u533b\u7642\u7528\u533b\u85ac\u54c1\u306e\u6dfb\u4ed8\u6587\u66f8\u60c5\u5831\u30b5\u30a4\u30c8\u3067\u6dfb\u4ed8\u6587\u66f8\u3084\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u30d5\u30a9\u30fc\u30e0\u304c\u5165\u624b\u3067\u304d\u307e\u3059\u306e\u3067\u8abf\u3079\u3066\u307f\u3066\u4e0b\u3055\u3044\u3002\u88fd\u9020\u5143\u3084\u8ca9\u58f2\u5143\u306e\u554f\u5408\u305b\u5148\u3082\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u3010\u53c2\u8003\u3011
\n\u533b\u7642\u7528\u533b\u85ac\u54c1\u306e\u6dfb\u4ed8\u6587\u66f8\u60c5\u5831\u3000-\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u3000\u533b\u85ac\u54c1\u533b\u7642\u6a5f\u5668\u7dcf\u5408\u6a5f\u69cb<\/a><\/span><\/p>\n\u30d5\u30a9\u30b7\u30fc\u30ac\u670d\u7528\u4e2d\u306b\u5c3f\u7d20\u7a92\u7d20\uff08BUN\uff09\u304c\u4e0a\u6607\u3057\u3066\u3057\u307e\u3063\u305fB\u3055\u307e\u306e\u5834\u5408<\/h3>\n
![\"\u8a3a\u5bdf\u3000\u5973\u6027\"](\"https:\/\/juntan.net\/blog\/wp-content\/uploads\/2022\/01\/6ebdb6a301bb3b22dbb2427c5663f517-450x300.jpg\")
\nB\u3055\u307e\u306f\u30d5\u30a9\u30b7\u30fc\u30ac\u958b\u59cb\u5f8c3\u304b\u6708\u76ee\u306e\u691c\u67fb\u3067\u5c3f\u7d20\u7a92\u7d20\uff08BUN\uff09\u304c2\u500d\u306b\u8df3\u306d\u4e0a\u304c\u3063\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u3084eGFR\u306b\u306f\u5927\u304d\u306a\u5909\u5316\u306f\u306a\u3044\u306e\u306b\u4f55\u6545\uff1f\u98df\u4e8b\u306e\u5185\u5bb9\u304c\u60aa\u304b\u3063\u305f\uff1f\u3068\u601d\u3063\u305f\u305d\u3046\u3067\u3059\u3002<\/p>\n
\n\u300e\uff08\u900f\u6790\u5c0e\u5165\u306e\u57fa\u6e96\u3068\u306a\u308b\u5c3f\u6bd2\u75c7\u75c7\u72b6\u306e\uff09\u9451\u5225\u306e\u306a\u304b\u3067\u7279\u306b\u8b70\u8ad6\u3068\u306a\u308b\u306e\u306f\u3001\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u304c2 mg\/dL\u7a0b\u5ea6\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001BUN\u304c100 mg\/dL\u4ee5\u4e0a\u3067\u3001\u98df\u6b32\u4f4e\u4e0b\u3084\u5026\u6020\u611f\u306a\u3069\u306e\u5c3f\u6bd2\u75c7\u75c7\u72b6\u3068\u601d\u308f\u308c\u308b\u75c7\u72b6\u304c\u3042\u308b\u3088\u3046\u306a\u72b6\u6cc1\u3067\u306f\u306a\u3044\u304b\u3068\u500b\u4eba\u7684\u306b\u306f\u601d\u3046\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u3088\u304f\u900f\u6790\u5c0e\u5165\u306e\u4f9d\u983c\u3092\u53d7\u3051\u308b\u304c<\/span>\u2026\uff08\u4e2d\u7565\uff09\u2026\u6d88\u5316\u7ba1\u51fa\u8840\u3001\u5faa\u74b0\u8840\u6f3f\u91cf\u306e\u4f4e\u4e0b\uff08\u8131\u6c34\uff09\u3001\u30bf\u30f3\u30d1\u30af\u8ca0\u8377\u3068\u3044\u3063\u305f\u3001\u3044\u308f\u3086\u308bBUN\/\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u75c5\u614b\u3092\u3057\u3063\u304b\u308a\u9664\u5916\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b<\/span>\u300f<\/p>\n
\n\u3053\u306e\u526f\u4f5c\u7528\u3092\u77e5\u3063\u3066\u3044\u305fB\u3055\u307e\u306f\u6bce\u65e51.5\uff5e2.0\u30ea\u30c3\u30c8\u30eb\u306e\u6c34\u5206\u6442\u53d6\u3092\u5fc3\u304c\u3051\u3066\u3044\u307e\u3057\u305f\u304c\u30012021\u5e7412\u6708\u306e\u691c\u67fb\u3067\u306fBUN\/\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u304c\u6025\u4e0a\u6607\u3057\u3066\u304a\u308a\u3001\uff08\u8d64\u8840\u7403\u3084HbA1c\u306a\u3069\u3082\u5897\u52a0\u3057\u3066\u3044\u305f\u3053\u3068\u304b\u3089\uff09\u3001\u8131\u6c34\u72b6\u614b\u3068\u5224\u65ad\u3055\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n
\nBUN\/\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u3068\u306f\u4f55\u304b\uff1f\u3000-\u516c\u76ca\u793e\u56e3\u6cd5\u4eba\u798f\u5ca1\u770c\u85ac\u5264\u5e2b\u4f1a<\/a>
\n\u60a3\u8005\u3055\u3093\u306f\u8131\u6c34\u75c7\u72b6\u3067\u306f\u306a\u3044\u3067\u3059\u304b\uff1f\u3000-\u9577\u5d0e\u770c\u5cf6\u539f\u75c5\u9662NST\uff08\u6804\u990a\u30b5\u30dd\u30fc\u30c8\u30c1\u30fc\u30e0\uff09<\/a><\/span><\/p>\nSGLT2\u963b\u5bb3\u85ac\u3001\u65e5\u672c\u4eba\u3067\u306e\u814e\u4fdd\u8b77\u52b9\u679c\u306f\uff1f<\/h2>\n
![\"\u81e8\u5e8a\u8a66\u9a13\u3000\u5973\u533b\u3000\u533b\u5e2b\u3000\u8a66\u9a13\"](\"https:\/\/juntan.net\/blog\/wp-content\/uploads\/2021\/09\/2bdddf1bd6d6fbd53c285bb59c37b99b-450x300.jpg\")
\n\u30e1\u30c7\u30a3\u30ab\u30eb\u30c8\u30ea\u30d3\u30e5\u30fc\u30f3\uff37eb\u7248\uff082021\u5e7411\u67089\u65e5\uff09\u3067\u5831\u9053\u3055\u308c\u305f\u5ddd\u5d0e\u533b\u79d1\u5927\u5b66\uff08\u9577\u6d32\u4e00\u5148\u751f\uff09\u3068\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\uff08\u77e2\u91ce\u88d5\u4e00\u6717\u5148\u751f\u3089\uff09\u306e\u5171\u540c\u7814\u7a76\u6210\u679c\u306b\u3088\u308b\u3068\u30012\u578b\u7cd6\u5c3f\u75c5\uff08\u6ce8\uff09\u306e\u65e5\u672c\u4eba\u306b\u304a\u3044\u3066\u4ee5\u4e0b\u306e\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002
\n\uff11\uff09eGFR\u306e\u5e74\u9593\u4f4e\u4e0b\u7387\u306fSGLT2\u963b\u5bb3\u85ac\uff08\u30d5\u30a9\u30b7\u30fc\u30ac\u4ee5\u5916\u306eSGLT2\u963b\u5bb3\u85ac\u3082\u542b\u3080\uff09\u3067-0.47\u3001\u4ed6\u306e\u8840\u7cd6\u964d\u4e0b\u85ac\u3067\u306f-1.22\u3067\u3042\u308aSGLT2\u963b\u5bb3\u85ac\u3067\u660e\u3089\u304b\u306beGFR\u4f4e\u4e0b\u306f\u7de9\u3084\u304b\u306b\u306a\u3063\u305f\u3002
\n\uff12\uff09\u5e73\u57472\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306beGFR\u304c50\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u307e\u305f\u306f\u900f\u6790\u5c0e\u5165\u306b\u81f3\u3063\u305f103\u4f8b\u306e\u5185\u8a33\u306fSGLT2\u963b\u5bb3\u85ac\u306730\u4f8b\u3001\u4ed6\u306e\u8840\u7cd6\u964d\u4e0b\u85ac\u306773\u4f8b\u3067\u3042\u308a\u3001SGLT2\u963b\u5bb3\u85ac\u3067\u6709\u610f\u306b\u5c11\u306a\u304b\u3063\u305f\u3002
\n\u3010\u53c2\u8003\u3011
\nKidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database\u3000-Diabetes Care 2021; 44: 2542-2551<\/a><\/span><\/p>\n\u304a\u308f\u308a\u306b<\/h2>\n
![\"\u7537\u6027\u533b\u5e2b\u3000\u85ac\u306e\u8aac\u660e\u3000\u51e6\u65b9\"](\"https:\/\/juntan.net\/blog\/wp-content\/uploads\/2021\/09\/0c88e757c0b5faeab9bbfa511309e003-450x307.jpg\")
\n\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001\u30d5\u30a9\u30b7\u30fc\u30ac\u306b\u4ee3\u8868\u3055\u308c\u308bSGLT2\u963b\u5bb3\u85ac\u306f\u65e5\u672c\u4eba\u306e\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u306a\u3055\u305d\u3046\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u672c\u30d6\u30ed\u30b0\u3067\u3054\u7d39\u4ecb\u3057\u305fA\u3055\u307e\u306e\u3088\u3046\u306b\u4e00\u904e\u6027\u306beGFR\u304c\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3063\u305f\u308a\u3001B\u3055\u307e\u306e\u3088\u3046\u306b\u8131\u6c34\u304c\u751f\u3058\u3066\u3057\u307e\u3046\u5834\u5408\u304c\u3042\u308b\u306e\u3067\u3001\u691c\u67fb\u5024\u3092\u898b\u306a\u304c\u3089\u3088\u308a\u826f\u3044\u85ac\u52b9\u304c\u5f97\u3089\u308c\u308b\u3088\u3046\u306b\u6c17\u9577\u306b\u69d8\u5b50\u3092\u898b\u5b88\u3063\u3066\u304f\u3060\u3055\u3044\u306d\u3002<\/p>\n
\n\u814e\u81d3\u75c5\u306e\u8840\u6db2\u691c\u67fb\u306e\u8aad\u307f\u65b9\u2460\u8ca7\u8840\u7de8<\/span><\/a>
\n\u814e\u81d3\u75c5\u306e\u8840\u6db2\u691c\u67fb\u306e\u8aad\u307f\u65b9\u2461\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u30fb\u5c3f\u7d20\u7a92\u7d20\u30fb\u30a2\u30eb\u30d6\u30df\u30f3<\/a><\/span>
\n\u814e\u81d3\u75c5\u306e\u8840\u6db2\u691c\u67fb\u306e\u8aad\u307f\u65b9\u2462\u30ab\u30ea\u30a6\u30e0\u7de8<\/a><\/span>
\n\u814e\u81d3\u75c5\u306e\u8840\u6db2\u691c\u67fb\u306e\u8aad\u307f\u65b9\u2463\u30ea\u30f3\u7de8<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"